Sampson starred as Wayne Duffy in the series Party Tricks in 2014 and as Bear Gerhardt in the TV series Fargo in 2015. He has starred in the movies Darkness Falls, Fat Pizza, Razor Eaters, You and Your Stupid Mate, Kodoka, Footy Legends, Where the Wild Things Are, I Love You Too, Insidious, Blinder, Insidious: Chapter 2, Mad Max: Fury Road, and Insidious: Chapter 3. He has written and directed the 2014 film The Mule and wrote for the TV series Greeks on the Roof. Sampson has been nominated for awards from the Australian Film Critics Association Awards, the Australian Film Institute, and the SXSW Film Festival.