In 2009 he won the MX1-GP FIM Motocross World Championship and defended it in 2010, 2011, 2012, 2013, and MXGP 2014. In 2012 and 2013 he won every Motocross des Nations event he raced in. Cairoli raced for Yamaha from 2004 to 2009 and has raced for KTM since 2010. He has won 72 Grands Prix and eight championships and has 144 wins to his name. In 2012 he won his 50th GP in World Championship in the Czech Republic.
