Slayton has been featured on many radio shows including Howard Stern, Tom Leykis, and Kevin & Bean. He has released the comedy albums Raging Bully, I’ve Come For Your Children, Built For Destruction, and Born To Be Bobby. He has starred in the movies Martians Go Home, Wayne’s World 2, Ed Wood, Get Shorty, Loser, Bandits, The Third Wheel, Dickie Roberts: Former Child Star, Dreamgirls, and A Beautiful Now. Slayton has also appeared in episodes of the TV series Clueless, The Tom Show, Home Improvement, Brother’s Keeper, Family Guy, The Mind of the Married Man, and Sonny with a Chance. In 1989 Slayton won an American Comedy Award for Comedy Club Stand-Up Comic – Male.