Breno Giacomini was drafted by the Green Bay Packers with the 150th pick (5th round) in the 2008 NFL Draft. He was mostly a practice squad player with the Packers, and in 2010 he was acquired by the Seahawks, though he was soon released thereafter. Prior to the 2011 season, the Seahawks resigned Giacomini, and he played in 15 games during the year. During the 2012 season, he started every game for Seattle, including both of their playoff games. Giacomini suffered a knee injury during the 2013 season, limiting him to only nine starts. He played for the Jets during the 2014-2016 seasons. He began playing for the Texans in 2017.