Neff had has first film role in the 2010 movie Amigo. His best known role has been as Jimmy Chance in the Fox sitcom Raising Hope since 2010. In 2014 he starred in and wrote an episode of the TV mini-series 7p/10e. Neff also produced and will star in the 2014 movie Glitch. He has also appeared in the 2011 movie In Memoriam and the 2013 short Delicious Ambiguity. Neff’s play “The Last Duck” was nominated for a 2012 Non-Equity Joseph Jefferson Award for New Work.