She has starred in the films Harry and Tonto, Gable and Lombard, Car Wash, The Great Smokey Roadblock, You Light Up My Life, Girlfriends, Heartbeeps, Missing, The Boss’ Wife, Sticky Fingers, Checking Out, My Blue Heaven, Drop Zone, and more. Mayron won a Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series for Thirtysomething in 1989. She has directed episodes of several TV series including Thirtysomething, Nash Bridges, New York Undercover, Arli$$, Tell Me You Love Me, In Treatment, The Naked Brothers Band, Greek, Drop Dead Diva, Easy to Assemble, Army Wives, The Fosters, Chasing Life, Switched at Birth, Pretty Little Liars, and Jane the Virgin.