Sweeney was a five-time All-Star in 2000, 2001, 2002, 2003, and 2005. He finished his career with a .297 batting average, 215 home runs, and 909 runs batted in. Sweeney is very active in his community, working to improve poorer parts of Kansas City. He is an outspoken Catholic and has been involved in several efforts to curb embryonic stem cell research. He has been married to Shara Nettles, daughter of ex-MLB player Jim Nettles, since 2002. They have three children together: daughter McKara and sons Michael and Donovan.