She has appeared on the TV shows Seinfeld, Melrose Place, Ed, Friends, The Chronicle, Spin City, Ghost Whisperer, 24, NCIS, Blind Justice, Heroes, Dirty Sexy Money, Bones, and Two and a Half Men. Sofer has appeared in the movies Keeping the Faith, A Stranger Among Us, The Secret of Hidden Lake, Carrie (2002), and the TV movies Always and Forever and Saved by the Bell: Hawaiian Style. Rena married director and producer Sanford Bookstaver in 2003 and the couple have a son. Their wedding was featured in InStyle Magazine in 2004. She was formerly married to General Hospital co-star Wally Kurth and had a daughter.